Satellite meeting for GlycoBiology?

Topics

Create and discuss about Taverna wolkflows for GycoBiology?.

Keywords:

• GlycoEpitopeDB  http://www.glyco.is.ritsumei.ac.jp/epitope/
• H-InvDB  http://h-invitational.jp/
• RINGS  http://rings.t.soka.ac.jp/
• Consortium for Functional Glycomics (CFG)  http://www.functionalglycomics.org
• GlycomeDB  http://www.glycome-db.org
• (GlycoGeneDB)  http://riodb.ibase.aist.go.jp/rcmg/ggdb/

• relations to diseases and SNPs
  • OMIM  http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim

Chairperson

• Kiyoko F. Aoki-Kinoshita

Members

• Shujiro Okuda
• Shin Kawano
• Chisato Yamasaki

Targets

• Develop and register web services on BioMoby? such that glycobiologists can create workflows for glycobiology research.
  • GlycoEpitopeDB:
    • Query GlycoEpitope? DB using a query and retrieve all IDs of entries containing the keyword.
    • Retrieve glycan structures in IUPAC format using GlycoEpitope? IDs.
  • RINGS:
    • Convert a glycan structure in IUPAC format into KCF format, by which glycan structure queries can be made.

• Create a workflow for analyzing glyco-gene-related diseases: Use OMIM to search for diseases related to loci of human homologs of target genes from other species, such as fruit fly. Retrieve any SNPs that are known to be related.

Summary

It took longer than expected, but we were able to create a BioMoby? web service in GlycoEpitope?.

• GlycoEpitope?
  • getGlycoEpitopeIDfromKeyword
  • getIUPACfromGlycoEpitopeID
• RINGS
  • getKCFfromIUPAC

Our workflow thus takes as input a keyword and searches GlycoEpitopeDB for entries matching the keyword. The retrieved entries are then used to get the glycan structures from each entry in IUPAC format. A new utility in RINGS was then developed to convert from IUPAC to KCF format. In an additional step, we retrieved similar glycan structures to the converted ones in KCF format. Both RINGS and GlycoEpitope? will continue to develop other web services with which to build workflows.

The disease-related workflow was able to retrieve H-Inv entries containing the OMIM Ids which were retrieved from OMIM for entries containing a particular keyword. The issue is that the output is in XML and contains entries which do not contain any SNPs, which we want to filter out. Tom showed us how to make a beanshell script which can be added to the workflow, and it worked!

Room

Select one:

• Chura Hall (3F)